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Obesity-linked diabetes in the Arab world: a review
EMHJ-Eastern Mediterranean Health Journal. 2015; 21 (6): 420-439
de En | IMEMR | ID: emr-164871
Bibliothèque responsable: EMRO
The Arab world is experiencing an epidemic of obesity and type 2 diabetes mellitus. This review summarizes the major pathological factors linking obesity to diabetes, focussing on current epidemiological data related to obese diabetic patients in the Arab world, the etiology of the disease and the genetic determinants of diabetes and obesity. There are alarming data related to the rising prevalence of obesity and type 2 diabetes mellitus in children of Arab ethnicity. Replication studies identify several genetic variants in Arabs with obesity-linked diabetes. For example, variants of the ADIPOQ gene [the rs266729 single-nucleotide polymorphism] are associated with obesity and diabetes in various Arab countries. Gaps exist in our information about diabetes and obesity in Arabpopulations in relation to ethnic-specific cut-off points for diagnosis and treatment of diabetes. Further genome-wide association studies in obese and diabetic Arab populations could add to our understanding of the pathophysiology, prevention and reversal of this disease
Sujet(s)
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Indice: IMEMR Sujet Principal: Monde arabe / Diabète / Diabète de type 2 / Obésité Type d'étude: Prognostic_studies Limites du sujet: Humans langue: En Texte intégral: East Mediterr Health J. Année: 2015
Recherche sur Google
Indice: IMEMR Sujet Principal: Monde arabe / Diabète / Diabète de type 2 / Obésité Type d'étude: Prognostic_studies Limites du sujet: Humans langue: En Texte intégral: East Mediterr Health J. Année: 2015