Efficacy of dydrogesterone in the management of threatened miscarriage in the first trimester

ABSTRACT

To study the efficacy of dydrogesterone in pregnant women with threatened miscarriage in the first trimester. Randomized control trial. Department of Obstetrics and Gynaecology, Military Hospital Rawalpindi from Jan 2008 to Dec 2008. One hundred and fifty two pregnant women presenting to the Gynae and Obs department [MH Rwp] before 12[th] gestational week were selected on the basis of slight pain or vaginal bleeding, no cervical dilatation and a viable pregnancy on ultrasound. They were divided randomly into two groups each containing 76 patients with the help of simple random number table, after obtaining their consent and explaining all the risks and benefits to them. Bias was controlled by double blinding. Patients in group A received oral dydrogesterone [10mg twice daily] and patients in group B received placebo. Treatment was continued till the 12[th] gestational week and patients were followed up 4 weekly after the completion of treatment till the 20[th] gestational week. Improvement was judged by continuation of pregnancy and remittance of symptoms. Patients in group A had a greater improvement in the symptoms of pain and vaginal bleeding but the difference between the two groups was not statistically significant. However the number of patients who had a normal growth and whose pregnancies continued was significantly higher in group A. It was concluded that the continuing pregnancy success rate was significantly higher in women treated with dydrogesterone compared with women who received placebo treatment