Cholestatic jaundice induced by carbimazole in grave's disease

Antithyroid medications are one of the treatment options for Grave's disease. Carbimazole [the pro drug for methimazole] is widely used as the drug of choice, except in pregnancy where propythiouracil is preferred by many. It is generally well-tolerated. Its side-effects include allergy, upper gastrointestinal upset, the rare occurrence of a granulocytosis and others. Hepatitis is another rare but serious side-effect. We report a previously healthy 65-year-old female patient with Grave's disease who developed cholestatic jaundice after carbimazole therapy. She made a full recovery after the drug was discontinued