Antiapoptotic effect of deprenyl in sensory neurons of rat dorsal root ganglion after sciatic nerve transection

ABSTRACT

Study on antiapoptotic effect of Deprenyl insensory neurons of dorsal root ganglion of rat. White Sprague-Dawley rats. The regions ofoperation were sciatic nerve in midthigh and L dorsal rootganglion. New born rats [3rd days] were divided intofive groups and their left side sciatic nerves weretransected at midthigh region.Five test groups wereadministered by deprenyl in different doses of 0.1, 1, 10,25 and50 mg/Kg and the antiapoptotic effect of drug werecompared with control group.Statistical analysis: The values obtained from each testgroups were compared with control group by t-test andoneway ANOVA. The results showed that treatment of animal withdeprenyl prevented reduction in neurons number, in dosedependent manner. The group treated with dose 25mg/Kgshowed the better results. Deprenyl is able to prevent the induction ofapoptosis in axotomized and nonaxotomizedneurons