effect of ubiquinone on functional recovery and morphometric indices of sciatic nerve regeneration

ABSTRACT

A common cause of peripheral nerve injury is trauma. The positive effect of antioxidants on the improvement of nerve regeneration has currently become a focus of attention. In this experiment, the effect of intraperitoneal administration of ubiquinone [CoQ10] on an acute experimentally sciatic nerve crush was studied in a rat model. Forty-five male Wistar rats, weighing between 160-180 g were used. The rats were randomly divided into two experimental groups [n=20]. Each group was further subdivided into four subgroups of five animals each. Functional studies confirmed the faster recovery of regenerated axons in the treatment group compared to the un-treated group [P<0.05]. Morphometric indices of the regenerated fibers showed the number and diameter of the myelinated fibers to be significantly higher in the treatment group than the un-treated group [P<0.05] Intraperitoneal administration of CoQ10 [10 mg/kg/day] in the early inflammatory stage of sciatic nerve crush was found to improve nerve regeneration