Epidemiologic features of inflammatory bowel disease in Guilan Province, North of Iran, during 2002-2012

ABSTRACT

The geographical incidence of IBD varies considerably. This study aimed to survey the epidemiologic features of IBD in Guilan province, North of Iran, during ten years duration. In this retrospective cross-sectional study, we assessed the documents of 868 patients with IBD referred to private and governmental clinics of Guilan province between 2002 and 2012. Variables such as demographic data, risk factors, diagnosis, extraintestinal manifestations and type of treatment were collected. Among 868 patients with IBD, 756 patients [87.1%] diagnosed as UC and 112 patients [12.9%] as CD. The mean age of patients with UC and CD was 46.73 +/- 15.79 and 40.15 +/- 14.27 years respectively. Male/female ratio in UC and CD was 0.921 and 0.751 respectively. The most common age of disease initiation in UC was 40-59 years and in CD 20-39 years [p<0.001]. Extraintestinal manifestations were seen in 25.4 percent of patients with IBD. Most of patients were treated with combination of two drugs salicylates and azathioprine [p<0.04]. The incidence of IBD gradually increased during the past 4 years in Guilan province. This study showed that CD were presented significantly more common in younger patients than UC and totally the disease was slightly more common in female