Studies on the effects of cyclodextrin polymer as a tableting aid on some selected analgesics

ABSTRACT

The clinical effectiveness of tablets depends on at least two factors; [i] the medication must be present in labeled amount [ii] it must be availble to the body. The drug availability is usually determined by the rate of release of drug from the tablet, which is governed by the processes of disintegration and dissolution. In present study, the effect of beta-Cyclodextrin on disintegration and rate of dissolution of analgesic tablets [paracetamol] have been studied. The results show that the tablets containing beta-Cyclodextrin polymer as a disintegrant enhances the rate of dissolution and reduces the disintegration time as compared to the commercially available tablets which lack beta-Cyclodextrin