Metallothionein lower under-expression in benign tumors than that in malignant tumors: systematic review article and meta-analysis
Iranian Journal of Public Health. 2014; 43 (6): 696-704
Dans Anglais
| IMEMR
| ID: emr-167587
ABSTRACT
Metallothionein [MT] manifests varying expression levels in carcinomas, and they may be considered as valuable cell cancerization biomarkers for diagnosis of patients with cancers. A meta-analysis was conducted to evaluate comprehensively the MT expression difference in various benign tumors and malignant tumors, which compared the high with low MT expression levels in patients of the available studies. Finally, a total of 13 studies dealing with various tumors were involved for this meta-analysis. The results indicated that lower expression of MT in various benign tumors tissue than that in corresponding malignant tumors with the pooled OR of 0.52 [95 % CI 0.18-1.47, P <0.001]. In conclusion, MT expression difference is associated with tumor various stages in tumor patients and could be a useful clinical criteria of distinguishing benign tumors and malignant tumors for those patients
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Indice:
Méditerranée orientale
Sujet Principal:
Méta-analyse comme sujet
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Tumeurs
Type d'étude:
Revues systématiques évaluées
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Iran. J. Public Health
Année:
2014
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