Status of lipid profile in different stages of chronic kidney disease

ABSTRACT

To estimate and compare dyslipidemia in patients with different stages of chronic kidney disease as compared to healthy controls and to determine whether dyslipidemia is independently associated with rapid renal impairment. This study was conducted in department of Biochemistry Basic Medical Institute [BMSI], Jinnah Postgraduate Medical Centre [JPMC] Karachi. A total of 150 participants were recruited for the study from the Nephrology department of JPMC. These were grouped as 30 stage II CKD patient, 30 stage III CKD patient, 30 stage IV CKD patient, 30 stage V CKD patient and 30 normal healthy individuals. Cholesterol, triglyceride, high density lipoprotein, low density lipoprotein, urea and creatinine were measured by commercially available kit method. Statistical analysis was done using SPSS version 11. Serum Cholesterol, Triglyceride and LDL-C among all groups were significantly increased when compared with control p<0.05. Serum HDL-C among all study groups was significantly decreased p<0.05, along with increase in LDL / HDL ratio among all study groups when compared with control p<0.05. Dyslipidemia occurs gradually in CKD patients as disease progresses. Evaluation of dyslipidemia in early stages of CKD is useful to assess the risk for future cardiovascular disease in these patients