T lymphocyte activation and expression of costimulatory molecules in intestinal Ascariasis

ABSTRACT

This study was carried on 48 patient with Ascriasis and 12 cross matched healthy control persons. All the studied cases were submitted to flow cytometric analysis of peripheral blood mononuclear cells using monoclonal antibodies against CD3, CD4, CD8, CD28, HLA-DR. In this study, there was a significant decrease in CD3, CD4 and expression of costimulatory molecule CD28 on CD8 T lymphocytes but the decrease in CD8 T lymphocytes was insignificant, while the activation marker HLA-DR expression on CD4 T lymphocytes was increased