in-vitro effect of albumin on platelet aggregation in patients with hypoalbuminaemia

ABSTRACT

Platelet aggregation induced by adenosine diphosphate [ADP] was studied in 25 patients with hypoalbuminaemia due to different pathology, before and after addition of 2 different volumes of concentrated albumin solution. The work revealed that the in vitro of addition of albumin to platelet rich plasma [PRP] to reach approximately the normal serum albumin level resulted in a significant decrease of maximum aggregation percent in patients with hypoalbuminaemia. No significant correlation was found between serum albumin level and maximum aggregation percent before the addition of albumin. It was concluded that the correction of hypoalbuminaemia by albumin infusion in nephrotic patients could be of great value to diminish the incidence of thrombotic complications in such patients