Comparison between the effects of the alcholic extract of mellissia officinalis and atorvastatin on serum levels of thyroid hormones in hypercholesterolemic male rats

ABSTRACT

Consumption of unsaturated fats reduces the serum level of lipids and leptin. Thyroid hormones and leptin play pivotal roles in metabolism and their amounts are interrelated. This study was done to compare the effects of Mellissia officinalis extract and atorvastatin on the serum levels of thyroid hormones in hypercholesterolemia rats. Consumption of unsaturated fats reduces the serum level of lipids and leptin. Thyroid hormones and leptin play pivotal roles in metabolism and their amounts are inter-related. This study was done to compare the effects of Mellissia officinalis extract and atorvastatin on the serum levels of thyroid hormones in hypercholesterolemia rats. The results showed that in experimental groups receiving the plant extract and atorvastatin, the concentration of thyroid hormones increased, whereas the amount of the thyroid-stimulating hormone showed a significant decrease [p<0.05]. Mellissia officinalis extract decreases TSH but it increases T3 and T4. Further studies are required for applying this extract to the treatment of hyperthyroidism