[ antibiotic resistance pattern of staphylococcus aureus isolated from patients in quaem university hospital during 2009-2011]

ABSTRACT

Staphylococcus aureus is a major human pathogen. Due to the high prevalence of S. aureus infections and increasing resistance to antibiotics, physicians have been facing problems in choosing an appropriate empirical antibiotic therapy. The aim of this study was to determine the pattern of antibiotic resistance among S. aureus clinical isolates in Quaem university hospital between 2009 and 2011. In this study 100 isolates of Staphylococcus aureus were identified in laboratory from different specimens. The specimens were collected and examined by standard diagnostic methods. Determination of S. aureus sensitivity to antibiotics was performed using standard disc diffusion method. The antibiotic sensitivity of bacteria were reported according to the Clinical Laboratory Standards Institute [CLSI] manual with sensitive [S], intermediate [I] and resistant [R]. Among antibiotics tested, Staphylococci isolates were highly resistant against Penicillin 97%, followed by, Oxacillin 63% Erythromycin 57%, Cephalexin 43% Clindamycin 33% Vancomycin 20%. Our results are similar to the reports from many other parts of Iran. According to this study, resistance pattern among Staphylococcus aureus strains was widespread in Quaem hospital. The implication of this high resistance is that Staphylococcus aureus infections should be treated with more precaution and not with Penicillin and other ineffective antibiotics