Effect of water soluble soybean fiber [WSSF] on bone changes induced by ovariectomy in female albino rat. a light and scanning electron microscopic study

ABSTRACT

Ovarian hormone deficiency impairs Ca absorption and decreases bone mineral density. Osteoporosis and other modern diseases like cancer and coronary heart disease are thought to be associated with consumption of westernized food that is deficient in fiber. Soybean and soybean products are popular foods in Japan. The lower incidence of osteoporosis in Japanese women is attributed to the high intake of soybean products. Thirty five adult female albino rats were used in the current study to evaluate the role of water soluble soybean fiber [WSSF] in amelioration of bone changes that might result from ovariectomy [artificial menopause]. Animals were divided into 3 groups. Group I, served as a control group. Group II, comprised the Sham operated rats. Group III, was firmed of ovariectomized rats, and was further divided into 2 subgroups. Subgroup IIIa, comprised the ovariectomized rats that received ordinary standard diet. Subgroup IIIb, was composed of ovariectomized rats that received diet supplemented with WSSE. Ovariectomy in the present study resulted in a statistically highly significant reduction in the mean cortical and trabecular bone thickness. The periosteum shoved decreased cellularity. The mean number of osteoclasts was increased per high power field. Cortical bone demomostated few Haversian canals amid there was osteolysis in the core of bone trabeculae. The mean serum levels of osteocalcin and alkaline phosphatase enzyme were decreased. Diet enriched with WSSF ameliorated the structural and biochemical osteoporotic changes induced by ovariectomy. Dietary consumption of' WSSF was very effective in ameliorating the bone mineral loss that resulted from ovariectomy. So, it is recommended that WSSF is advised to be added to the diet in order to achieve a satisfactory bone quality after menopause