effect of chlorpromazine and peserpine on sex hormone level in serum and on liver function tests

ABSTRACT

The effect of the major tranquilizer [chlorpromazine] and the antihypertensive agent [reserpine] on serum testosterone [TS], follicular stimulating hormone [FS H], leutinizing hormone [LEE] and liver enzymes [AST, ALT] as well as total protein [UP], albumin [ALB] and free amino acids [AA] in male albino rats were investigated. Drug treatment was given s.c. for 30 days after which, animals were sacrificed, the testes from each animal were carefull9 removed and weighed. Both drugs caused a significant reduction in testicular weight. Chlorpromazine resulted in a significant decrease [p<0.01] in the levels of [TS], [FSH] [LEE] and [ALT]. Reserpine resulted in a significant' decrease [p<0.01] in serum