Urinary markers for early detection of Diabetic Nephropathy in type 1 Diabetes Mellitus
Egyptian Journal of Hospital Medicine [The]. 2015; 61 (October): 479-488
Dans Anglais
| IMEMR
| ID: emr-173905
ABSTRACT
Background:
diabetic nephropathy [DN] is a serious complication of diabetic mellitus associated with increased risk of morbidity and mortality. Diagnostic markers to detect DN at early stage are important as early intervention can slow loss of kidney functions and improve patient outcomes. N-acetyl Beta d-glucosaminidase [NAG] is a lysosomal enzyme, present in high concentrations in renal proximal tubular cells, Gamma-glutamyltransferase [GGT] is an enzyme which located along the proximal tubular brush border, Malondialdehyde [MDA] is a highly toxic product, formed in part by lipid oxidation derived free radicals, Reactive carbonyl derivatives [RCD[S]] is an oxidative stress marker in urine, as a measure of the oxidative modification of proteins and beta-2-microglobulin is filtered by the glomerulus, absorbed and catabolized by the proximal tubules. The aim of this study is to investigate the urinary outcome of these markers as early detectors of diabetic nephropathy in type 1 diabetic children
Recherche sur Google
Indice:
Méditerranée orientale
Sujet Principal:
Acetylglucosaminidase
/
Bêta-2-Microglobuline
/
Stress oxydatif
/
Diabète de type 1
/
Gamma-Glutamyltransferase
/
Malonaldéhyde
Type d'étude:
Étude de dépistage
Limites du sujet:
Enfant
/
Femelle
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Egypt. J. Hosp. Med.
Année:
2015
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