Myokines in alcoholic myopathy

ABSTRACT

Objective: Interleukin [IL]-15 is highly expressed in skeletal muscles, where it exerts anabolic effects, increase protein content in muscle fibres and promotes muscle growth. Alcoholics frequently suffer myopathy. Therefore, we analyse the level of IL-15 [and other myokines, such as tumor necrosis factor-alpha [TNF-alpha]] in alcoholics. Follow-up of skeletal muscle cytokines [myokines] such as IL-15 and TNF-alpha level in alcoholism, in an attempt to reveal if a certain level of myokines can be considered as a risk factor for short-term motility