Small molecule-BIO accelerates and enhances marrow-derived mesenchymal stem cell in vitro chondrogenesis

ABSTRACT

Background: Hyaline cartilage defects exhibit a major challenge in the field of orthopedic surgery owing to its limited repair capacity. On the other hand, mesenchymal stem cells [MSCs] are regarded as potent cells with a property of cartilage regeneration. We aimed to optimize marrow-derived MSC chondrogenic culture using a small bioactive molecule referred to as BIO