Synergistic cytotoxic effect of gold nanoparticles and 5-aminolevulinic acid-mediated photodynamic therapy against skin cancer cells

ABSTRACT

Background: Photodynamic therapy [PDT] is a promising therapeutic modality for the treatment of cancer and other diseases. In this study, the epidermoid carcinoma cell line A431 and the normal fibroblasts were used to investigate whether gold nanoparticles [GNPs] can induce an increase in cell death during PDT using 5-aminolevulinic acid [5-ALA] as a photosensitizer