Study the effect of endocannabinoid system on rat behavior in elevated plus-maze

ABSTRACT

Introduction: Previous studies have shown that cannabinoidergic system is involved in anxiety. However, there are controversial reports in the experimental studies. The aim of this study is to evaluate the effect of pharmacological stimulation or blocking of CB1 receptors and inhibition of endocannabinoid degradation in anxiety like behavior in elevated plus-maze [EPM] test in rat. The EPM is one of the most widely used animal models of anxiety