Association of IGF-1 gene [rs5742612] polymorphism with colorectal cancer

ABSTRACT

Background: Insulin-like growth factor 1 has an important role in cell proliferation and growth. Polymorphism in IGF-1 gene changes the level of this hormone and increases the risk of colorectal cancer. The aim of this study is to assess the incidence of IGF-1 polymorphism rs5742612 in Iranian population and to investigate the influence of this polymorphism in increasing the risk of colorectal cancer