Anti-Acanthamoeba Activities of Chloroformic Fractions of Trigonella Foenum Graecum [Seed] and Their Cytotoxity on Mice Macrophage Cell

ABSTRACT

Background: Acanthamoeba keratitis [AK] is potentially a sight-threatening infection and its treatment is challenging. This is mainly due to presence of resistant cyst form. Indeed, cysts are highly resistant to current available drugs. Chemical drugs are toxic to human keratocytes. It should also be mentioned that most available anti-Acanthamoeba drugs are poorly cysticidal, In Iran and worldwide, AK cases continue to rise and therefore, novel effective drugs are urgently needed for the treatment of AK.