Your browser doesn't support javascript.
loading
Experimental study of the possible effect of valsartan on insulin resistance in fructose- fed albino rats
Mansoura Medical Journal. 2006; 37 (1-2): 363-379
Dans Anglais | IMEMR | ID: emr-182176
ABSTRACT
Insulin resistance [IR] is a consequence of high fructose fed diet in rats. The current study was carried out to declare if tumor necrosis factor alpha [TNF-alpha] exerts a partial role the development of IR in non-obese rat model; fructose fed rats [FFR] like that happens in obese rat models. We evaluate the influence of valsartan [a selective blocker of angiotensin receptor type-1] in comparison to metformin [a known insulin sensitizer] on enhancement of insulin sensitivity in FFR. Rats were divided into 2 equal groups [36 rats /group], one group received high fructose diet to induce insulin resistance and the other included standard diet fed rats. Each group is further divided into 3 equal subgroups, [standard diet+ saline], [FFR+ saline], [Standard diet + metformin], [FFR+ metformin]. [Standard diet+ valsartan] and [FFR+ valsartan]. In all rats, body weight, fasting serum glucose, fasting serum insulin, insulin sensitivity test, fasting glucose insulin ratio [FGIR], serum TNF-alpha and serum malondialdehyde [MDA] were measured. Result revealed that administration of valsartan to FFR produced a comparable improvement of insulin resistance. In addition valsartan treatment in FFR produced significant decrease in serum TNF-alpha and MDA. It could be concluded that TNF-alpha and angiotensin II might regulate insulin sensitivity in non-obese FFR
Sujets)
Recherche sur Google
Indice: Méditerranée orientale Sujet Principal: Rats / Valine / Facteur de nécrose tumorale alpha / Souris de lignée NOD / Récepteur de type 1 à l'angiotensine-II / Fructose / Malonaldéhyde / Metformine Limites du sujet: Animaux langue: Anglais Texte intégral: Mansoura Med. J. Année: 2006

Documents relatifs à ce sujet

MEDLINE

...
LILACS

LIS

Recherche sur Google
Indice: Méditerranée orientale Sujet Principal: Rats / Valine / Facteur de nécrose tumorale alpha / Souris de lignée NOD / Récepteur de type 1 à l'angiotensine-II / Fructose / Malonaldéhyde / Metformine Limites du sujet: Animaux langue: Anglais Texte intégral: Mansoura Med. J. Année: 2006