Flavonoids of retama raetam, and in vitro antitumor screening of two isoflavones

ABSTRACT

From the aerial parts of Retama raefam ten flavonoids were isolated and identified as saponarin, genistein 8-C-glucoside, genistein 5-O- methylether, genistein 5,4'-di-O-methylether, alpuminoisoflavone, ephedroidin, luteolin, apigenin and two new flavones, luteolin 4'-O- neohesperidoside and 5,4'-dihydroxy- [3",4''- dihydro- [3",4"-dihdroxy] -2",2"dimethylpyrano [5",6"7,8]-flavone[1]. In vitro antitumor screening of genistein-5-O-methylether and genistein-8-C-glucoside were carried out on sixty human tumor cell lines