Predictive values of TNF-alpha, IL-6, IL-10 for radiation Pneumonitis
International Journal of Radiation Research. 2016; 14 (3): 173-179
Dans Anglais
| IMEMR
| ID: emr-183214
ABSTRACT
Background:
To investigate the expression of TNF-alpha, IL-6, IL-10 in the plasma of patients with lung cancer who received radiation therapy [RT], and to analyze the correlation between these cytokines and radiation pneumonitis [RP]. Materials andMethods:
Patients with lung cancer who received 3D-CRT in our hospital were prospectively evaluated. Circulating cytokine levels were measured with ELISA before RT and at the end of RT. Regular follow-up was undertaken 3 months after RT. Statistical analysis was applied to determine the relevance of cytokines to radiation-induced lung injury.Results:
Of 104 patients, 29 [27.9%] developed RP. The levels of TNF-alpha and IL-6 levels in the plasma after RT were significantly higher than before RT [p<0.05], whereas IL -10 levels were significantly lower after RT than before RT [p<0.05]. Before RT, TNF-alpha levels were higher in RP group [p<0.05],but there were no differences in TNF-alpha levels after RT. No association was observed between IL-6 and IL-10 levels and the risk of RP. Univariate analysis showed that baseline pulmonary function, smoking history, histopathology, lung volume receiving >/=20 Gy [V20], Mean lung dose [MLD] and total radiation dose were related to RP, but only MLD was an independent risk factor for RP in lung cancer patients [OR>1].Conclusion:
TNF-alpha levels in plasma were closely related to RP but still cannot be used as predictors for RP
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Indice:
Méditerranée orientale
langue:
Anglais
Texte intégral:
Int. J. Radiat. Res.
Année:
2016
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