Histopathological and immunohistochemical evaluation of antifibrogenic effect of grape seed extract on CCl4-induced model of hepatic fibrosis

ABSTRACT

Introduction: Liver fibrosis represent a worldwide challenge of clinical importance, results from chronic damage of liver, and evidenced by build up of excessive extracellular matrix proteins.. The present study was carried out to evaluate the antifibrogenic effect of grape seed extract [GSE] against hepatic fibrosis induced by CCl4 in mice