Overexpression of recombinant human teriparatide, rhPTH [1-34] in Escherichia coli: an innovative gene fusion approach
AJMB-Avicenna Journal of Medical Biotechnology. 2017; 9 (1): 19-22
Dans Anglais
| IMEMR
| ID: emr-185808
ABSTRACT
Background:
Parathyroid hormone is an 84-amino acid peptide secreted by the parathyroid glands. Its physiological role is maintenance of normal serum calcium level and bone remodeling. Biological activity of this hormone is related to N-terminal 1-34 amino acids. The recombinant form of hormone [1-34] has been approved for treatment of osteoporosis from 2002. In this study, a novel fusion partner has been developed for preparation of high yield recombinant 1-34 amino acids of hPTH
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Indice:
Méditerranée orientale
Sujet Principal:
Protéines de fusion recombinantes
/
Clonage moléculaire
/
Fusion artificielle de gènes
/
Escherichia coli
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Avicenna J. Med. Biotechnol.
Année:
2017
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