Effects of garlic [Allium sativum] extract on the expression of receptor for advanced glycation end products and proinflammatory cytokines secretion in peripheral blood mononuclear cells from patients with type 2 diabetes mellitus

ABSTRACT

Background: receptor for advanced glycation end products [RAGE] plays a causative role in diabetes. Garlic [Allium sativum] belongs to compounds with anti-glycation activity that can be considered as probable therapeutic approaches in delaying or preventing the onset of diabetes complications. The aim of this study was to evaluate the influence of garlic on the RAGE expression and proinflammatory cytokines secretion in peripheral blood mononuclear cells [PBMCs] from patients with type 2 diabetes mellitus