Evaluation of ED[50] and 5alpha-reductase inhibitor activities of some thiopyrimidine, pyrane, pyrazoline and thiazolopyrimidine derivatives

ABSTRACT

In this work, twenty-one thiopyrimidine [1-21] candidates containing a pyrane, pyrazoline and thiazolopyrimidine ring screened for their ED[50] and 5alpha-reductase inhibitors comparable to that of Anastrozole as positive drug. Some of the tested product showed moderate 5alpha-reductase inhibitors with lower toxicity. The detailed ED[50] and 5alpha-reductase inhibitor activities of the synthesized compounds were studied