Serotonin transporter gene [SLC6A4] polymorphism and mucosal serotonin levels in Southeastern Iranian patients with irritable bowel syndrome

ABSTRACT

Irritable bowel syndrome [IBS] is a digestive system disorder with an unknown etiology. Serotonin has a key role in the secretion and motility of the intestine. Polymorphism in serotonin re-uptake transporter [SERT or SLC6A4] gene may have a functional role in the gut of patients with IBS. The aims of the present study were to investigate the association between SLC6A4 gene polymorphism and IBS and to detect the correlation between rectal serotonin levels and IBS sub-types