Tumor necrosis factor Alpha -308 G/A single nucleotide polymorphism and risk of sperm abnormalities in Iranian males

ABSTRACT

Background: Signaling molecules such as cytokines regulate spermatogenesis during the maturation of germ cells and sperm apoptosis. Tumor necrosis factor alpha [TNF alpha] is one of the most-documented cytokines that is involved in spermatogenesis. We investigated the association of the TNF alpha -308 G/A single nucleotide polymorphism with sperm abnormalities in Iranian males