Impacts of multiple-field irradiation and boron concentration on the treatment of boron neutron capture therapy for non-small cell lung cancer

ABSTRACT

Background: Boron neutron capture therapy [BNCT] is a radiotherapy that combines biological targeting and high linear energy transfer. A potential therapeutic approach for non-small cell lung cancer [NSCLC] is considered. However, dose in lung tumor is not homogeneous, and it will reduce the effect of BNCT treatment. In order to improve the dose distribution of BNCT, the multi-field irradiation strategy and its effects need to be explored