Genotype-phenotype association of TGF-pi and GST with chemo-radiotherapy induced toxicity
International Journal of Radiation Research. 2017; 15 (1): 15-23
Dans Anglais
| IMEMR
| ID: emr-187492
ABSTRACT
Background:
Normal tissue toxicity continues to remain as a major challenge for radiation oncologists for delivering the total dose to the tumour cells in cancer patients. Cellular, molecular and plasma based early biomarkers to predict the overreactions and non-overreactions of normal tissue toxicity before the initiation of radiotherapy can be valuable for personalised treatment. The aim of the current study was to analyse the interrelationship between polymorphisms in Glutathione S- Transferases [GSTs] and Transforming Growth Factor-pi [TGF-J31], the plasma level/activity of these proteins with the development of chemo-radiotherapy induced oral mucositis and skin reaction in head and neck cancer [HNC] patients
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Indice:
Méditerranée orientale
Sujet Principal:
Radiodermite
/
Radiothérapie
/
Stomatite
/
Toxidermies
/
Glutathione S-transferase pi
/
Études d'associations génétiques
Limites du sujet:
Adulte
/
Adulte très âgé
/
Femelle
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Int. J. Radiat. Res.
Année:
2017
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