Application of derivative spectrophotometry to the determination of each of metoclopramide HCL and lignocaine HCL in pharmaceutical preparations

ABSTRACT

Derivative spectrophotometric methods were described for the determination of metoclopramide HCl and lignocaine HCl in dosage forms. The first drug was determined in suppositories, syrups, ampoules, tablets and drops. The second was determined in vials, jelly and ointments. The methods were efficient to correct for the interference due to additives viz. parabens and coadministered drugs as paracetamol and naphazoline. Results obtained were accurate with coefficient of variation less than 2%