In vitro effects of wistar rat prenatal and postnatal cerebrospinal fluid on neural differentiation and proliferation of mesenchymal stromal cells derived from bone marrow

ABSTRACT

Objective: cerebrospinal fluid [CSF] plays an important role in cortical development during the fetal stages. Embryonic CSF [E-CSF] consists of numerous neurotrophic and growth factors that regulate neurogenesis, differentiation, and proliferation. Mesenchymal stem cells [MSCs] are multi-potential stem cells that can differentiate into mesenchymal and non-mesenchymal cells, including neural cells. This study evaluates the prenatal and postnatal effects of CSF on proliferation and neural differentiation of bone marrow MSCs [BM-MSCs] at gestational ages E19, E20, and the first day after birth [P1]