Analysis of NSP4 gene and its association with genotyping of rotavirus group a in stool samples

ABSTRACT

Background: Non-structural protein 4 [NSP4] is a critical protein for rotavirus [RV] replication and assembly. This protein has multiple domains and motifs that predispose its function and activity. NSP4 has a sequence divergence in human and animal RVs. Recently, 14 genotypes [E1-E14] of NSP4 have been identified, and E1 and E2 have been shown to be the most common genotypes in human