Assessment of bone morphogenetic protein 3 methylation in Iranian patients with colorectal cancer

ABSTRACT

Background: Colorectal cancer [CRC] is a common cancer that results in outstanding morbidity and mortality worldwide. DNA methylation is one of the most important epigenetic events that is thought to occur during the early stages of oncogenic transformation especially in CRC. The aim of this study was to investigate whether hypermethylation of bone morphogenetic protein 3 [BMP3] in tissue samples is implicated in Iranian patients with CRC