High density lipoprotein subfractions and apolipoprotein-A1[Apo-A1] In chronic hemodialysis patients

ABSTRACT

Cholesterol content in high density lipoprotein [HDL] subfractions and the serum concentration of opoprotein A-1 [Apo-A1] have been studied in 32 patients at the end stage of chronic renal failure [CRF] undergoing haemodialysis. High density lipoprotein-cholesterol [HDL-C] subfractions were significantly decreased in the patient's group compared to the control group. However, serum concentrations of Apo-A1 were not significantly different. The raised Apo-A1/HDL2 cholesterol ratio in the patients group suggests the existence of qualitative changes in HDL subfractions in patients with CRF receiving haemodialysis. The abnormalities in the relative composition of HDL subfractions could play an important role as a cardiovascular risk factor in patients with CRF undergoing haemodialysis