V279F polymorphism might change protein character and immunogenicity in Lp-PLA2 protein

ABSTRACT

Background: Lipoprotein-associated phospholipase A2 [Lp-PLA2] plays a strong role in the occurrence of certain cardiovascular disease processes. Polymorphisms at the protein level are also estimated to correlate with increased risk factors for heart attacks. One such polymorphism is the V279F polymorphism in Lp-PLA2 which results in a change in enzyme performance capability. This in turn implies a reduced risk of acute myocardial infarct [AMI] in Korean and Indonesian subpopulations