Antibiotic supplements affect electrophysiological properties and excitability of rat hippocampal pyramidal neurons in primary culture

ABSTRACT

Introduction: antibiotic supplements are regularly used in neuronal culture media to control contamination; however, they can interfere with the neuronal excitability and affect electrophysiological properties. Therefore, in this study, the effect of penicillin/streptomycin supplements on the spontaneous electrophysiological activity of hippocampal pyramidal neurons was examined