Effect of glucose loading on uric acid clearance in cases of primary hyperuricaemia

ABSTRACT

The effect of glucose loading on uric acid clearance was studied in 15 male nondiabetic patients with primary hyperuricemia in addition to 16 normouricemic nondiabetic male subjects as controls. Serum glucose, uric acid and creatinine clearances were measured before and during oral glucose tolerance test [OGTT] along 3 hours [0.5, 1, 2 and 3 hours] after glucose intake [1 g of glucose/kg body weight]. The serum glucose levels of fasting and at one and two hours after glucose intake were significantly higher in the hyperuricemic group than the control group. Uric acid clearance before and after glucose intake did not change significantly in both control and hyperuricemic groups. There was no significant difference between both groups as regards the clearance ratio of uric acid to creatinine [Cua/Ccr] before and during OGTT. Also, there was no correlation between serum glucose level and Cua/Ccr ratio in both groups before and during OGTT. From these results, it could be concluded that glucose loading has no effect on uric acid clearance in cases of primary hyperuricemia