study on hepatitis B surface [Bs] antigen and auto-antibodies in patients with fascioliasis

ABSTRACT

A considerable, unexplained liver damage was reported in human fascioliasis. The present work explored the probability of adjoined hepatitis B surface [HB[S]] antigen and auto immunity in intensification of this pathological state. Nineteen patients with chronic infection were examined clinically. The intensity of infection and specific antibody level determined. The haematological parameters and liver functions were studied. Search for HB[S] antigen, anti nuclear and anti mitochondrial antibodies was undertaken. Hepatitis B surface [HB[S]] antigen and antimitochondrial antibodies were not detected in any case. Antinuclear antibodies were observed in cases with relatively high infection intensity. It was concluded that an auto immune process might intensify the liver injury initiated by fasciola infection