[Shigella dysentery stxA mutant [R170L-A231D-G234E] gene design and optimization of recombinant protein expression and purification]
Journal of Shahrekord University of Medical Sciences. 2011; 13 (5): 93-102
Dans Persan
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| ID: emr-194676
ABSTRACT
Background and aims:
Shigella dysentery is one of the most important human pathogenic intestinal bacteria. Entrance of the shigella toxin into the epithelial cells inhibits protein synthesis leading to cell death. In spite of great investigations on vaccine production against S. dysentery, studying to achieve significant stxA recombinant protein still remains important. The objective of this study was to determine the appropriate mutation loci and designing stxA subunit synthetic gene, its further expression and optimization and ultimately assaying purification method for further immunization studies
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Indice:
Méditerranée orientale
langue:
Persan
Texte intégral:
J. Shahrekord Univ. Med. Sci.
Année:
2011
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