Effect of feeding different levels of shark J cartilage powder [SCP] on serum mineral profiles hepatic detoxifying enzymes and immunological indices of experimental rats

ABSTRACT

The study aimed to find out the potential effect of natural SCP in four concentrations on the improvement of I immunity, mineral state and hepatic detoxifying enzymes activity on the experimental rates. Rats showed increase in serum calcium, phosphorus, magnesium, zinc and iodine levels with the increase of SCP. Obtained data showed significant increases in serum iron, hemoglobin and hematocrite levels at 1.0%, 2.5% and 5% of SCP feed proportions in rats groups. There was nonsignificant increase in firitin levels with the increase of SCP concentrations in the experimental rats diet Investigated data showed an elevation of hepatic detoxification enzymes activity with the elevation of SCP concentration in rats diets. There were significant increases in GSSGR; GSHP and GST values at 1.0%, 2.5% and 5.0% SCP feed proportions in the diet. Data illustrated improvement of investigated immune parameters with SCP supplementation. There were non-significant increases in total immunoglobulin levels in all SCP feed groups. IgG, CD + 4 and CD+8 values increased non-significantly with 0.5% and 1.0% SCP feed proportions and significantly with 2.5% and 5.0% SCP feed proportions. Shark cartilage concentrations 2.5% and 5.0% achieved best obtained results in our research, so we recommended these concentrations for good therapeutic effect of SCP?