Maternal history and uterine artery wave form in the prediction of early-onset and late-onset preeclampsia: a cohort study

Background: Pregnancy induced hypertension [PIH] is a significant cause of maternal morbidity and mortality. Pregnancy-induced-hypertension can be prevented by identification of prenatal and antenatal factors. The uterine artery Doppler waveform transforms into a high flow with low resistance at 22-24 wk

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Objective: To study the maternal risk factors and uterine artery Doppler waveform in singleton mid-trimester pregnancy and predict the occurrence of pregnancy-induced hypertension

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Materials and methods: This is a cohort study comprising of Doppler ultrasound examination of the uterine arteries at 20-23 wk gestation in 697 women with singleton pregnancies attending a routine target scan. The pregnant women were followed up. PIH was recorded in 57 [8.18%] of all pregnancies

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Results: Maternal age >34 yr, primiparity, the presence of chronic hypertension was also associated with increased risk of PIH. High pulsatility index [>95th percentile] as compared to low pulsatility index was a good tool for the detection of PIH [sensitivity 91.23% and specificity 99.06%, p<0.05]. Presence of high pulsatility was a significant risk factor for early-onset PIH as compared to late-onset PIH

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Conclusion: Uterine artery Doppler can be safely performed at the time of routine target anomaly scan in the second trimester. It is simple, economical, feasible and with good detection rates