Preparation method of penicillin V postassium Beta-cyclodextrin inclusion
Pakistan Journal of Pharmaceutical Sciences. 2018; 31 (4 [Special]): 1633-1638
Dans Anglais
| IMEMR
| ID: emr-199257
ABSTRACT
In order to conceal the unpleasant smell of pharmaceutical raw materials of penicillin V potassium, we use Beta-cyclodextrin [Beta-CD] as a drug carrier. The Penicillin V potassium Beta-CD inclusion complex was prepared by saturated aqueous solution method; the characterization of penicillin V potassium Beta-CD inclusion complex is determined by scanning electron microscopy, Differential Scanning Calorimeter [DSC] and X-ray Diffraction [XRD], the formation constants of the complexes were determined by UV spectrophotometry; based on the results obtained from the orthogonal experimental design, the optimum preparation process are summarized as follow Beta-CD Penicillin V potassium = 4 1 [molar ratio], stirring temperature 50 centigrade, strirring time 12h, the encapsulation efficiency is 29.40%
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Indice:
Méditerranée orientale
langue:
Anglais
Texte intégral:
Pak. J. Pharm. Sci.
Année:
2018
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