Decrease in cavity size and oligodendrocyte cell death using Neurosphere-Derived oligodendrocyte-like cells in spinal cord contusion model

ABSTRACT

Background: Oligodendrocyte cell death is among the important features of spinal cord injury, which appears within 15 min and occurs intensely for 4 h after injury, in the rat spinal contusion model. Accordingly, the number of oligodendrocytes progressively reduced within 24 h after injury. Administration of oligodendrocyte-like cells [OLCs] into the lesion area is one of the approaches to counterbalance this condition