Evaluation of the additive effect of domperidone on patients with refractory gastroesophageal reflux disease; a randomized double blind clinical trial

ABSTRACT

Background: Gastroesophageal reflux disease [GERD] is a common problem with annoying symptoms. It is associated with negative impact on quality of life. Prokinetic agents may be used in combination with acid suppression agents as an adjunctive in patients with GERD refractory to proton pump inhibitors [PPI] therapy, rather than as sole treatment. This study aimed to evaluate the efficacy of combination of PPI with domperidone [a prokinetic agent] compared with PPI alone in the treatment of patients with refractory GERD