[Study of the effect of Zn2+,W6+ and V5+ on insulin secretion and glukokinase activation of pancreatic islets obtained from normal and diabetic rats]

ABSTRACT

Insulin dependant Diabetes Mellitus [IDDM] is associated with a reduction in production or secretion of insulin from pancreatic Islets. On the other hand increase in insulin secretion will result in destruction of islets that will lead to Diabetes .Therefore the factors that could regulate secretion will prevent the onset of diabetes. Glucose metabolism that commences with the glucokinase action is closely related to insulin secretion. The aim of this study is to survey the effect of eat ions Zn2+, V5+ and W5+ on insulin secretion and on the key enzyme, glucokinase, which is known to play an important role in insulin secretion