Age-related changes in the mRNA expression of antioxidant enzymes in rat prostate: quantification by RT-PCR

ABSTRACT

Background: Aging is associated with oxidative stress results in damage to cellular structures. Oxidative stress has been linked to many diseases, including prostate diseases. The rat prostate is composed of several distinct lobes the ventral lobe [VL], lateral lobe [LL], and dorsal lobe [DL]. Each prostatic lobe is different in its morphology, secretions, and response to hormones. The aim of this study is to determine the mRNA expression of three major antioxidant enzymes, glutathione peroxidase [GPx], glutathione reductase [GR], and superoxide dismutase [SOD], in aged rat prostate